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Primary aldosteronism, also known as primary hyperaldosteronism or Conn's syndrome, is excess production of the hormone aldosterone by the adrenal glands resulting in low renin levels. Often it produces few symptoms.〔 Most people have high blood pressure which may cause poor vision or headaches.〔〔(【引用サイトリンク】url=http://endocrinediseases.org/adrenal/hyperaldosteronism_symptoms.shtml )〕 Occasionally there may be muscular weakness, muscle spasms, tingling sensations, or excessive urination.〔 Complications include cardiovascular disease such as stroke, myocardial infarction, kidney failure, and abnormal heart rhythms.〔〔 Primary hyperaldosteronism has a number of causes. About 66% of cases are due to enlargement of both adrenal glands and 33% of cases are due to an adrenal adenoma that produces aldosterone.〔 Other uncommon causes include adrenal cancer and an inherited disorder called familial hyperaldosteronism.〔(【引用サイトリンク】url=http://endocrinediseases.org/adrenal/hyperaldosteronism.shtml )〕 Some recommend screening people with high blood pressure who are at increased risk while others recommend screening all people with high blood pressure for the disease. Screening is usually done by measuring the aldosterone-to-renin ratio in the blood with further testing used to confirm positive results. While low blood potassium is classically described this is only present in about a quarter of people. To determine the underlying cause medical imaging is carried out. Some cases may be cured by removing the adenoma by surgery.〔 A single adrenal gland may also be removed in cases where only one is enlarged.〔(【引用サイトリンク】url=http://endocrinediseases.org/adrenal/hyperaldosteronism_treatment.shtml )〕 In cases due to enlargement of both glands treatment is typically with medications known as aldosterone antagonists such as spironolactone or eplerenone.〔 Other medications for high blood pressure and a low salt diet may also be needed.〔〔 Some people with familial hyperaldosteronism may be treated with the steroid dexamethasone.〔 Primary aldosteronism is present in about 10% of people with high blood pressure.〔 It occurs more often in women than men. Often it begins in those between 30 and 50 years of age. Conn's syndrome is named after Jerome W. Conn (1907–1994), the American endocrinologist who first described adenomas as a cause of the condition in 1955. ==Signs and symptoms== People often have few or no symptoms.〔 They may get occasional muscular weakness, muscle spasms, tingling sensations, or excessive urination.〔 High blood pressure, manifestations of muscle cramps (due to hyperexcitability of neurons secondary to low blood calcium), muscle weakness (due to hypoexcitability of skeletal muscles secondary to hypokalemia), and headaches (due to low blood potassium or high blood pressure) may be seen. Secondary hyperaldosteronism is often related to decreased cardiac output which is associated with elevated renin levels. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Primary aldosteronism」の詳細全文を読む スポンサード リンク
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